Study shows MRSA impacts survival of individuals with cystic fibrosis

June 17, 2010

A recent study reported in The Journal of the American Medical Association (JAMA) aimed to determine whether the isolation of methicillin-resistant Staphylococcus aureus (MRSA) from the respiratory tract of individuals with cystic fibrosis (CF) was associated with a worsened chance of survival as compared to those who never had a positive culture for MRSA. The researchers’ conclusion was that the detection of MRSA in CF patients’ respiratory tracts was indeed associated with worse survival even when adjusting for severity of illness.

The U.S. Cystic Fibrosis Foundation Registry was utilized for the study.

MRSA is an important emerging pathogen for patients with cystic fibrosis.

The authors noted an important finding that the detection of MRSA was associated with a risk of death 1.27 times higher than those individuals without MRSA. The findings suggest that MRSA can be a “modifiable risk factor for death” in patients with CF.

Referenced Article: Dasenbrook, E.C., Checkley, W., Merio, C. A., Konstan, M. W., Lechtzin, N., and M. P. Boyle. Association Between Respiratory Tract Methicillin-Resistant Staphylococcus aureus and Survival in Cystic Fibrosis. JAMA, 303(23):2386-2392 (2010).

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